Detailed view for EmuJ_000574300

Basic information

TDR Targets ID: 964822
Echinococcus multilocularis, nephrin
Source Database / ID:  GeneDB

pI: 7.7543 | Length (AA): 1536 | MW (Da): 171109 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07686   Immunoglobulin V-set domain
PF08205   CD80-like C2-set immunoglobulin domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
32 705 5oj2 (A) 24 615 27.00 0.000082 1 0.371302 1.58
56 149 1pko (A) 15 122 20.00 0 0.37 0.0932979 -0.41
56 144 4ofi (A) 94 184 36.00 0 1 0.503043 -0.83
488 998 3dmk (A) 353 763 26.00 0.0027 0.97 0.166182 2.14
541 577 4jvu (B) 240 283 46.00 0.82 0.28 0.375589 0.87
731 819 5vl3 (R) 200 288 33.00 0.13 0.05 0.112443 2.11
881 1067 2xy2 (A) 21 162 37.00 0.0092 0.17 -0.0477552 1.47
901 1237 4yfd (A) 148 420 27.00 0.000005 0.99 0.145901 1.43
1127 1222 5utk (A) 627 718 29.00 0.34 1 0.373 -0.2
1135 1238 2dju (A) 3 99 22.00 0 0.72 0.310808 -0.99
1140 1239 3teu (A) 2 93 20.00 0 0.25 0.229204 -1.02
1149 1216 4bqc (B) 891 961 40.00 0.63 1 0.226771 -0.62

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134110)

Species Accession Gene Product
Brugia malayi Bm1_39130   Immunoglobulin I-set domain containing protein
Caenorhabditis elegans CELE_C26G2.1   Protein SYG-2
Drosophila melanogaster Dmel_CG33141   sticks and stones
Drosophila melanogaster Dmel_CG7449   hibris
Echinococcus granulosus EgrG_000574300   nephrin
Echinococcus multilocularis EmuJ_000574300   nephrin
Homo sapiens ENSG00000161270   nephrosis 1, congenital, Finnish type (nephrin)
Loa Loa (eye worm) LOAG_01148   immunoglobulin I-set domain-containing protein
Mus musculus ENSMUSG00000006649   nephrosis 1, nephrin
Schistosoma japonicum Sjp_0116220   Kin of IRRE-like protein 2 precursor, putative
Schistosoma japonicum Sjp_0023900   Nephrin precursor, putative
Schistosoma japonicum Sjp_0023920   Nephrin precursor, putative
Schistosoma japonicum Sjp_0023910   expressed protein
Schistosoma mansoni Smp_130070   nephrin
Schmidtea mediterranea mk4.002992.12  
Schmidtea mediterranea mk4.007471.03  
Schmidtea mediterranea mk4.009432.00  
Schmidtea mediterranea mk4.005703.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.008 0.6062 0.5962
0.0085 0.2559 0.2559
0.0224 0.4315 0.7155
0.0364 0.3245 1
0.0253 0.379 1
0.0304 0.3987 0.892
0.0153 0.6731 0.9822
0.0393 0.4766 1
0.0049 0.6979 1
0.0452 0.7107 1
0.0135 0.5155 0.5155
0.0385 0.6376 1
0.0076 0.7193 1
0.0049 0.721 1
0.0106 0.5026 0.4899
0.0458 0.6828 1
0.0074 0.3192 0.3389
0.0409 0.4427 0.4876
0.0054 0.4651 1
0.0161 0.32 0.3149
0.0449 0.6473 1
0.0109 0.721 1
0.0372 0.6637 1
0.0266 0.3002 0.3002
0.0269 0.3521 1
0.0075 0.4288 0.4288
0.0076 0.6267 0.6162
0.0303 0.4809 0.506
0.0054 0.7018 0.5
0.0129 0.4117 0.1662
0.0073 0.7191 1
0.0073 0.3578 0.3578
0.0054 0.3822 0.3822
0.014 0.2948 1
0.0079 0.5265 0.5265
0.0018 0.4938 1
0.0081 0.6423 0.6152
0.0238 0.2699 0.2694
0.0289 0.4698 0.5755
0.0031 0.476 1
0.0238 0.2699 0.2694
0.0253 0.4155 0.8985
0.0039 0.4857 0.4857
0.0018 0.5533 1
0.0077 0.6236 1
0.0298 0.3987 0.8247
0.0072 0.4307 0.4307
0.0129 0.4117 0.1662
0.0054 0.2535 0.2511
0.0077 0.5524 0.5
0.0106 0.5026 0.4899
0.0039 0.5152 0.5152
0.0342 0.6198 1
0.0494 0.5335 0.5331
0.0054 0.7018 0.5
0.008 0.5441 0.5441
0.008 0.6771 0.6935
0.0081 0.5905 0.5807
0.0348 0.6176 0.8043
0.0074 0.2817 0.2747
0.0129 0.4117 0.1662
0.0072 0.7303 1
0.0075 0.7193 1
0.0134 0.4433 0.5143
0.0078 0.5863 0.5758
0.009 0.4863 1
0.0076 0.6149 1
0.008 0.5741 0.5741
0.0079 0.5275 0.5275
0.0303 0.4809 0.506
0.008 0.6326 1
0.008 0.5741 0.5741
0.0053 0.7046 0.5
0.0238 0.2699 0.2694
0.0197 0.4388 1
0.0314 0.2806 0.2788
0.0129 0.4117 0.1662
0.0074 0.355 0.3409
0.0225 0.6261 1
0.0225 0.6261 1
0.0049 0.721 1
0.0101 0.6716 1
0.0286 0.376 0.376
0.016 0.6756 1
0.0133 0.2555 0.2555
0.0074 0.2817 0.2747

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000574300 (Echinococcus multilocularis), nephrin
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